Article
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1993
Tisdale M, Kemp S D, Parry N R, Larder B A
Abstract excerpt
Resistant variants of human immunodeficiency virus type 1 (HIV-1) have been selected by limited passage in MT4 cells of both wild-type and 3'-azido-3'-deoxythymidine (AZT, zidovudine)-resistant strains with the nucleoside analogues (-)-2'-deoxy-3'-thiacytidine (3TC) and (-)-2'-deoxy-5-fluoro-3'-t...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Cell Line
- Conserved Sequence
- Deoxycytidine
- Drug Resistance, Microbial
- Genotype
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lamivudine
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Polymerase Chain Reaction