Article
Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat.
Physiological genomics - 22 Oct 2007
Moreno Carol, Kaldunski Mary L, Wang Tao, Roman Richard J, Greene Andrew S, Lazar Jozef, Jacob Howard J, Cowley Allen W
Abstract excerpt
Previous studies have indicated that substitution of chromosome 13 of the salt-resistant Brown Norway BN/SsNHsdMcwi (BN) rat into the genomic background of the Dahl salt-sensitive SS/JrHsdMcwi (SS) rat attenuates the development of salt-sensitive hypertension and renal damage. To identify the regions within chromosome 13 that attenuate the development of hypertension during a high-salt diet in the SS rat, we...
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