Article
Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension.
Physiological genomics - 3 Mar 2010
Lu Limin, Li Peigang, Yang Chun, Kurth Terry, Misale Michael, Skelton Meredith, Moreno Carol, Roman Richard J, Greene Andrew S, Jacob Howard J, Lazar Jozef, Liang Mingyu, Cowley Allen W
Abstract excerpt
Chromosome 13 consomic and congenic rat strains were analyzed to investigate the pattern of genomic pathway utilization involved in protection against salt-sensitive hypertension and renal injury. Introgression of the entire Brown-Norway chromosome 13 (consomic SS-13(BN)) or nonoverlapping segments of this chromosome (congenic strains, 16 Mbp in D13Rat151-D13Rat197 or 14 Mbp in D13Rat111-D13Got22) into the genome...
Topics
- Albuminuria
- Animals
- Animals, Congenic
- Chromosomes, Mammalian
- Gene Expression Profiling
- Gene Expression Regulation
- Genome
- Hypertension
- Inbreeding
- Kidney