Article
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains.
American journal of physiology. Heart and circulatory physiology - 1 Apr 2011
Moreno Carol, Williams Jan M, Lu Limin, Liang Mingyu, Lazar Jozef, Jacob Howard J, Cowley Allen W, Roman Richard J
Abstract excerpt
Transfer of chromosome 13 from the Brown Norway (BN) rat onto the Dahl salt-sensitive (SS) genetic background attenuates the development of hypertension, but the genes involved remain to be identified. The purpose of the present study was to confirm by telemetry that a congenic strain [SS.BN-(D13Hmgc37-D13Got22)/Mcwi, line 5], carrying a 13.4-Mb segment of BN chromosome 13 from position 32.4 to 45.8 Mb, is...
Topics
- Animals
- Animals, Congenic
- Base Sequence
- Chromosomes, Mammalian
- Genetic Loci
- Hypertension
- Kidney
- Male
- Molecular Sequence Data
- Polymorphism, Single Nucleotide
- Proteinuria
- Rats
- Rats, Inbred Dahl