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Article

Variants in DNA double-strand break repair genes and breast cancer susceptibility.

Human molecular genetics - 1 Jun 2002

Kuschel Bettina, Auranen Annika, McBride Simon, Novik Karen L, Antoniou Antonis, Lipscombe Julian M, Day Nicholas E, Easton Douglas F, Ponder Bruce A J, Pharoah Paul D P, Dunning Alison

Abstract excerpt

We performed genetic association studies in a population-based breast cancer case-control study analysing polymorphisms in genes involved in homologous recombination (NBS1, RAD52, RAD51, XRCC2 and XRCC3) and non-homologous end-joining (KU70/80 and LIG4). These DNA double-strand break repair genes are candidates for breast cancer susceptibility. Genotype results were available for up to 2205 cases and 1826...

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Source

Identifiers

PMID: 12023982
DOI: 10.1093/hmg/11.12.1399

Genes

XRCC3
LIG4
XRCC2
RAD51
RAD52

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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