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Article

Analysis of variants in DNA damage signalling genes in bladder cancer.

BMC medical genetics - 18 Jul 2008

Choudhury Ananya, Elliott Faye, Iles Mark M, Churchman Michael, Bristow Robert G, Bishop D Timothy, Kiltie Anne E

Abstract excerpt

BACKGROUND: Chemicals from occupational exposure and components of cigarette smoke can cause DNA damage in bladder urothelium. Failure to repair DNA damage by DNA repair proteins may result in mutations leading to genetic instability and the development of bladder cancer. Immunohistochemistry studies have shown DNA damage signal activation in precancerous bladder lesions which is lost on progression, suggesting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18638378
DOI: 10.1186/1471-2350-9-69
PMCID: PMC2488326

Genes

MRE11
ATM
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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