Article
Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2008
Pooley Karen A, Baynes Caroline, Driver Kristy E, Tyrer Jonathan, Azzato Elizabeth M, Pharoah Paul D P, Easton Douglas F, Ponder Bruce A J, Dunning Alison M
Abstract excerpt
The proteins involved in homologous recombination are instrumental in the error-free repair of dsDNA breakages, and common germ-line variations in these genes are, therefore, potential candidates for involvement in breast cancer development and progression. We carried out a search for common, low-penetrance susceptibility alleles by tagging the common variation in 13 genes in this pathway in a two-stage...
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