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Article

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk: a meta-analysis.

PloS one - 1 Jan 2013

Li Shan, Peng Qiliu, Chen Yongbin, You Jianpeng, Chen Zhiping, Deng Yan, Lao Xianjun, Wu Huiling, Qin Xue, Zeng Zhiyu

Abstract excerpt

BACKGROUND AND OBJECTIVE: The X-ray repair cross-complementing group 1 (XRCC1) protein plays a crucial role in base excision repair (BER) pathway by acting as a scaffold for other BER enzymes. Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer. Recent...

Topics

Asian People
DNA-Binding Proteins
Genetic Predisposition to Disease
Humans
Odds Ratio
Polymorphism, Genetic
Smoking
Urinary Bladder Neoplasms
X-ray Repair Cross Complementing Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24039945
DOI: 10.1371/journal.pone.0073448
PMCID: PMC3767803

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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