Article
Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.
Cancer research - 1 Sept 2009
Stern Mariana C, Lin Jie, Figueroa Jonine D, Kelsey Karl T, Kiltie Anne E, Yuan Jian-Min, Matullo Giuseppe, Fletcher Tony, Benhamou Simone, Taylor Jack A, Placidi Donatella, Zhang Zuo-Feng, Steineck Gunnar, Rothman Nathaniel, Kogevinas Manolis, Silverman Debra, Malats Nuria, Chanock Stephen, Wu Xifeng, Karagas Margaret R, Andrew Angeline S, Nelson Heather H, Bishop D Timothy, Sak Sei Chung, Choudhury Ananya, Barrett Jennifer H, Elliot Faye, Corral Román, Joshi Amit D, Gago-Dominguez Manuela, Cortessis Victoria K, Xiang Yong-Bing, Gao Yu-Tang, Vineis Paolo, Sacerdote Carlotta, Guarrera Simonetta, Polidoro Silvia, Allione Alessandra, Gurzau Eugen, Koppova Kvetoslava, Kumar Rajiv, Rudnai Peter, Porru Stefano, Carta Angela, Campagna Marcello, Arici Cecilia, Park Sung Shim Lani, Garcia-Closas Montserrat
Abstract excerpt
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of...
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