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Article

Interaction between polymorphisms of DNA repair genes significantly modulated bladder cancer risk.

International journal of medical sciences - 1 Jan 2012

Zhi Yi, Yu Jing, Liu Yang, Wei Quanfang, Yuan Fang, Zhou Xiaozhou, Song Bo, Chen Zhiwen, Yang Jin

Abstract excerpt

DNA repair is a primary defense mechanism against damage caused by exogenous and endogenous sources. We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls....

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to DNA-Activated Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Repair

Share to MutL Protein Homolog 1

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Share to Urinary Bladder Neoplasms

Share to X-ray Repair Cross Complementing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 22927776
DOI: 10.7150/ijms.4799
PMCID: PMC3427955

Genes

XRCC1
ATM
MLH1
XPC

Variants

Provenance

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