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Article

Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.

Human genetics - 1 May 2006

García-Closas Montserrat, Egan Kathleen M, Newcomb Polly A, Brinton Louise A, Titus-Ernstoff Linda, Chanock Stephen, Welch Robert, Lissowska Jolanta, Peplonska Beata, Szeszenia-Dabrowska Neonila, Zatonski Witold, Bardin-Mikolajczak Alicja, Struewing Jeffery P

Abstract excerpt

The double-strand break DNA repair pathway has been implicated in breast carcinogenesis. We evaluated the association between 19 polymorphisms in seven genes in this pathway (XRCC2, XRCC3, BRCA2, ZNF350, BRIP1, XRCC4, LIG4) and breast cancer risk in two population-based studies in USA (3,368 case...

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Source

Identifiers

PMID: 16485136
DOI: 10.1007/s00439-006-0135-z

Genes

XRCC3
BRCA2
XRCC2
BRIP1
LIG4
XRCC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16485136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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