Article
Genetic variation in the base excision repair pathway and bladder cancer risk.
Human genetics - 1 Apr 2007
Figueroa Jonine D, Malats Núria, Real Francisco X, Silverman Debra, Kogevinas Manolis, Chanock Stephen, Welch Robert, Dosemeci Mustafa, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Castaño-Vinyals Gemma, Rothman Nathaniel, García-Closas Montserrat
Abstract excerpt
Genetic polymorphisms in DNA repair genes may impact individual variation in DNA repair capacity and alter cancer risk. In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3). Using...
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