Article
Genetic variants in 8-oxoguanine DNA glycosylase 1 (OGG1) and X-ray repair cross-complementing protein 1 (XRCC1) and non-genetic factors are associated with bladder cancer susceptibility and prognosis in a Brazilian population.
Journal of toxicology and environmental health. Part A - 1 Jan 2026
de Souza Rodrigues Milene Roldão, da Silva Isabely Mayara, Leite Vacario Beatriz Geovana, Oliveira Rocha Luíza Magosso, Ikeda Kawasaki Julia Ayumi, Porto Rebeca Eloi S, Fuganti Paulo Emílio, Koike Alexsandro, Falco Mateus L, Guembarovski Roberta Losi, de Syllos Cólus Ilce Mara, Serpeloni Juliana Mara
Abstract excerpt
Cellular responses to DNA damage play a crucial role in carcinogenesis, particularly in environmentally related cancers such as bladder cancer (BC). This is the ninth most frequently occurring cancer globally and most frequent in the urinary system. Polymorphic variants in genes encoding DNA repair proteins may interfere with their expression and/or activity. Consequently, modulation in an individual's gene...
Topics
- Humans
- DNA Glycosylases
- Urinary Bladder Neoplasms
- Female
- X-ray Repair Cross Complementing Protein 1
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease