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Article

Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2007

Lu Baisong, Geurts Aron M, Poirier Christophe, Petit Deborah C, Harrison Wilbur, Overbeek Paul A, Bishop Colin E

Abstract excerpt

A significant barrier to exploiting the full potential of the rat as a biomedical model is the lack of tools to easily modify its germline. Here we show that a tyrosinase-tagged Sleeping Beauty transposon can be used as a simple, efficient method to generate rat mutants in vivo. By making two lines of transgenic rats, one carrying the transposon and another expressing the transposase in germ cells, we are able to...

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Share to Amino Acid Sequence
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Monophenol Monooxygenase

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Identifiers

PMID: 17557177
DOI: 10.1007/s00335-007-9025-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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