Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

Nature - 14 Jul 2005

Dupuy Adam J, Akagi Keiko, Largaespada David A, Copeland Neal G, Jenkins Nancy A

Abstract excerpt

Transposons have provided important genetic tools for functional genomic screens in lower eukaryotes but have proven less useful in higher eukaryotes because of their low transposition frequency. Here we show that Sleeping Beauty (SB), a member of the Tc1/mariner class of transposons, can be mobilized in mouse somatic cells at frequencies high enough to induce embryonic death and cancer in wild-type mice. Tumours...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo Loss
Share to Embryo, Mammalian
Share to Mammals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Insertional

Share to Oncogenes

Share to Receptor, Notch1

Share to Receptors, Cell Surface

Share to Transposases

Source

Identifiers

PMID: 16015321
DOI: 10.1038/nature03691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.PMID 16015321Read ↗

Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.Semantic proximity Read ↗

A DNA transposon-based approach to validate oncogenic mutations in the mouse.Semantic proximity Read ↗

Transposon mutagenesis disentangles osteosarcoma genetic drivers.Semantic proximity Read ↗

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.Semantic proximity Read ↗

Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology.Semantic proximity Read ↗

Efficient transposition of Tol2 in the mouse germline.Semantic proximity Read ↗

Nonviral Gene Delivery with the <i>Sleeping Beauty</i> Transposon SystemSemantic proximity Read ↗

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.Semantic proximity Read ↗

Going non-viral: theSleeping Beautytransposon system breaks on through to the clinical sideSemantic proximity Read ↗

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.Semantic proximity Read ↗

Genetic Signature of Histiocytic Sarcoma Revealed by a Sleeping Beauty Transposon Genetic Screen in MiceSemantic proximity Read ↗

Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.