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Article

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes.

G3 (Bethesda, Md.) - 4 Oct 2015

Elso Colleen M, Chu Edward P F, Alsayb May A, Mackin Leanne, Ivory Sean T, Ashton Michelle P, Bröer Stefan, Silveira Pablo A, Brodnicki Thomas C

Abstract excerpt

A number of different strategies have been used to identify genes for which genetic variation contributes to type 1 diabetes (T1D) pathogenesis. Genetic studies in humans have identified >40 loci that affect the risk for developing T1D, but the underlying causative alleles are often difficult to pinpoint or have subtle biological effects. A complementary strategy to identifying "natural" alleles in the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26438296
DOI: 10.1534/g3.115.021709
PMCID: PMC4683661

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