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Article

Chicken beta-globin 5'HS4 insulators function to reduce variability in transgenic founder mice.

Biochemical and biophysical research communications - 14 Jul 2000

Potts W, Tucker D, Wood H, Martin C

Abstract excerpt

Transgenic mice and rats play a vital role in the study of human diseases and the advancement of drug development within the pharmaceutical industry. In this report we describe a method which improves the yield of phenotypically desirable transgenic founder mice resulting from each microinjection session and consequently reduces animal requirements for transgenic production. We have shown that by flanking a...

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PMID: 10891364
DOI: 10.1006/bbrc.2000.3013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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