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Article

Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.

Development (Cambridge, England) - 1 May 2011

Besse Laurianne, Neti Mariame, Anselme Isabelle, Gerhardt Christoph, Rüther Ulrich, Laclef Christine, Schneider-Maunoury Sylvie

Abstract excerpt

Primary cilia have essential functions in vertebrate development and signaling. However, little is known about cilia function in brain morphogenesis, a process that is severely affected in human ciliopathies. Here, we study telencephalic morphogenesis in a mouse mutant for the ciliopathy gene Ftm (Rpgrip1l). We show that the olfactory bulbs are present in an ectopic location in the telencephalon of Ftm(-/-)...

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Identifiers

PMID: 21490064
DOI: 10.1242/dev.059808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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