Article
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
The Journal of biological chemistry - 11 Oct 2013
Wang Chengbing, Low Wee-Chuang, Liu Aimin, Wang Baolin
Abstract excerpt
The primary cilium is required for Hedgehog signaling. So far, all known ciliogenic proteins regulate Hedgehog signaling through their role in ciliogenesis. Here we show that the mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First, DZIP1 interacts with GLI3, a transcriptional regulator for Hedgehog signaling, and prevents GLI3 from entering the nucleus. Second, DZIP1 is required for...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Line
- Cells, Cultured
- Centrioles
- Centrosome
- Cilia
- Cytoplasm
- Cytoskeletal Proteins
- DNA-Binding Proteins
- Embryo, Mammalian
- Fibroblasts
- HEK293 Cells
- Hedgehog Proteins