Article
Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.
Human molecular genetics - 1 Jul 2017
Wu Chuanqing, Li Jia, Peterson Andrew, Tao Kaixiong, Wang Baolin
Abstract excerpt
The Wdr34 gene encodes an intermediate chain of cytoplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia. Although mutations in human WDR34 have recently been reported, the association of WDR34 function with Hedgehog (Hh) signaling has not been established, and actual cilia defects in the WDR34 mutant cells have also not been completely characterized. In the present study, we...
Topics
- Animals
- Biological Transport
- Carrier Proteins
- Cell Culture Techniques
- Cell Movement
- Cilia
- Cytoplasmic Dyneins
- Dyneins
- Hedgehog Proteins
- Intracellular Signaling Peptides and Proteins