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Article

A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification

2024-03-02

Abstract excerpt

Studying developmental processes in the context of the human central nervous system is essential to understand neurodevelopmental diseases. In this paper we perform a comparative functional study of the ciliopathy gene RPGRIP1L in human and mouse spinal development using in vitro 3D differentiation of pluripotent stem cells. RPGRIP1L , a causal gene of severe neurodevelopmental ciliopathies such as Joubert and...

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Literature Corpus work
7cf6d434-1264-5071-9716-1c8398d04c4f
DOI
10.1101/2024.02.28.582477
Open publication

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A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specificationDOI 10.1101/2024.02.28.582477
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