Article
Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene.
Cancer chemotherapy and pharmacology - 1 Mar 2008
Bellott Ricardo, Le Morvan Valérie, Charasson Virginie, Laurand Armelle, Colotte Marthe, Zanger Ulrich M, Klein Kathrin, Smith Denis, Bonnet Jacques, Robert Jacques
Abstract excerpt
PURPOSE: Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. We previously identified a single nucleotide polymorphism (SNP), with an allele frequency around 10%, as possibly involved in enzyme expression (Clin Pharmacol Ther 76:528-535, 2004), which could explain the large individual variation in SN-38 disposition. METHODS: The 830C>G SNP,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.