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Article

ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2004

de Jong Floris A, Marsh Sharon, Mathijssen Ron H J, King Cristi, Verweij Jaap, Sparreboom Alex, McLeod Howard L

Abstract excerpt

PURPOSE: The ATP-binding cassette transporter ABCG2 (breast cancer resistance protein) is an efflux protein that plays a role in host detoxification of various xenobiotic substrates, including the irinotecan metabolite 7- ethyl-10-hydroxycamptothecin (SN-38). The ABCG2 421C>A polymorphism has been associated with reduced protein expression and altered function in vitro. The aim of this study was to evaluate the...

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Source

Identifiers

PMID: 15355921
DOI: 10.1158/1078-0432.CCR-04-0144

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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