Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.

doi:10.1111/j.1365-2125.2010.03695.x

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Article

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.

British journal of clinical pharmacology - 1 Aug 2010

Sai Kimie, Saito Yoshiro, Tatewaki Naoko, Hosokawa Masakiyo, Kaniwa Nahoko, Nishimaki-Mogami Tomoko, Naito Mikihiko, Sawada Jun-Ichi, Shirao Kuniaki, Hamaguchi Tetsuya, Yamamoto Noboru, Kunitoh Hideo, Tamura Tomohide, Yamada Yasuhide, Ohe Yuichiro, Yoshida Teruhiko, Minami Hironobu, Ohtsu Atsushi, Matsumura Yasuhiro, Saijo Nagahiro, Okuda Haruhiro

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Association of UDP-glucuronosyltransferase 1A1 (UGT1A1) genetic polymorphisms *6 and *28 with reduced clearance of SN-38 and severe neutropenia in irinotecan therapy was demonstrated in Japanese cancer patients. * The detailed gene structure of CES1 has been characterized. * Possible functional SNPs in the promoter region have been reported. WHAT THIS STUDY ADDS *...

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Identifiers

PMID: 20653675
DOI: 10.1111/j.1365-2125.2010.03695.x
PMCID: PMC2911552

Genes

CES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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