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Article

Association of genetic variation with irinotecan infusion reactions and severe toxicity.

Pharmacogenetics and genomics - 1 Oct 2025

Nugent Kelly I, Huang Lyucheng, Nazzal Maisa, Pasternak Amy L, Hertz Daniel L

Abstract excerpt

Irinotecan treatment is often complicated by gastrointestinal, hematological, and infusion-related toxicities, the latter of which typically presents as acute cholinergic syndrome (ACS). While genetic variation in UGT1A1 increases toxicity risk, fewer studies have investigated variation in other genes. This study aimed to assess the impact of variation in other genes involved in irinotecan pharmacokinetics with...

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Source

Identifiers

PMID: 40900652
DOI: 10.1097/FPC.0000000000000574

Genes

CES1
ABCG2
UGT1A1
ABCB1
ABCC2
CES2
SLCO1B1
UGT1A7
UGT1A9

Provenance

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