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Article

Clinical implications of genetic variation in carboxylesterase drug metabolism.

Expert opinion on drug metabolism & toxicology - 1 Feb 2018

Chen Feng, Zhang Bo, Parker Robert B, Laizure S Casey

Abstract excerpt

INTRODUCTION: Mammalian carboxylesterase enzymes are a highly conserved metabolic pathway involved in the metabolism of endogenous and exogenous compounds including many widely prescribed therapeutic agents. Recent advances in our understanding of genetic polymorphisms affecting enzyme activity have exposed potential therapeutic implications. Areas covered: The aims of this review are to provide an overview of...

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Share to Carboxylesterase
Share to Carboxylic Ester Hydrolases
Share to Cholinesterase and Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 29264996
DOI: 10.1080/17425255.2018.1420164

Genes

CES1
CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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