Article
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2005
Kubo Takashi, Kim Su-Ryang, Sai Kimie, Saito Yoshiro, Nakajima Toshiharu, Matsumoto Kenji, Saito Hirohisa, Shirao Kuniaki, Yamamoto Noboru, Minami Hironobu, Ohtsu Atsushi, Yoshida Teruhiko, Saijo Nagahiro, Ohno Yasuo, Ozawa Shogo, Sawada Jun-Ichi
Abstract excerpt
Twelve single nucleotide polymorphisms (SNPs) in the human CES2 gene, which encodes a carboxylesterase, hCE-2 [human carboxylesterase 2 (EC 3.1.1.1)], have been reported in the Japanese. In this report, we have examined functional alterations of three SNPs, a nonsynonymous SNP (100C>T, R34W), an SNP at the splice acceptor site in intron 8 (IVS8-2A>G), and one newly discovered nonsynonymous SNP (424G>A, V142M)....
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