Article
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1.
Clinical pharmacokinetics - 1 Nov 2023
de With Mirjam, van Doorn Leni, Kloet Esmay, van Veggel Anne, Matic Maja, de Neijs Micha J, Oomen-de Hoop Esther, van Meerten Esther, van Schaik Ron H N, Mathijssen Ron H J, Bins Sander
Abstract excerpt
BACKGROUND AND OBJECTIVE: Side effects of irinotecan treatment can be dose limiting and may impair quality of life. In this study, we investigated the correlation between single nucleotide polymorphisms (SNPs) in genes encoding enzymes involved in the irinotecan metabolism and transport, outside UGT1A1, and irinotecan-related toxicity. We focused on carboxylesterases, which are involved in formation of the active...
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