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Article

Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38.

Clinical pharmacology and therapeutics - 1 Dec 2004

Charasson Virginie, Bellott Ricardo, Meynard Delphine, Longy Michel, Gorry Philippe, Robert Jacques

Abstract excerpt

PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). The existence of functional polymorphisms in the gene encoding this enzyme could explain the individual variability in drug efficacy and toxicity. We have explored this possibility in looking for single nucleotide...

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Identifiers

PMID: 15592324
DOI: 10.1016/j.clpt.2004.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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