Article
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2007
Kim Su-Ryang, Sai Kimie, Tanaka-Kagawa Toshiko, Jinno Hideto, Ozawa Shogo, Kaniwa Nahoko, Saito Yoshiro, Akasawa Akira, Matsumoto Kenji, Saito Hirohisa, Kamatani Naoyuki, Shirao Kuniaki, Yamamoto Noboru, Yoshida Teruhiko, Minami Hironobu, Ohtsu Atsushi, Saijo Nagahiro, Sawada Jun-ichi
Abstract excerpt
Human carboxylesterase 2 (hCE-2) is a member of the serine esterase superfamily and is responsible for hydrolysis of a wide variety of xenobiotic and endogenous esters. hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). In this study, a comprehensive haplotype analysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.