Article
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
Clinical pharmacology and therapeutics - 1 Feb 2008
Shu Y, Brown C, Castro R A, Shi R J, Lin E T, Owen R P, Sheardown S A, Yue L, Burchard E G, Brett C M, Giacomini K M
Abstract excerpt
The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy volunteers with known OCT1 genotype agreed to participate in the study. Each subject received two oral doses of metformin followed by collection of blood and urine samples. OCT1 genotypes had a significant (P<0.05) effect on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.