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Article

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.

BioMed research international - 1 Jan 2013

Lozano Elisa, Herraez Elisa, Briz Oscar, Robledo Virginia S, Hernandez-Iglesias Jorge, Gonzalez-Hernandez Ana, Marin Jose J G

Abstract excerpt

Changes in the uptake of many drugs by the target cells may dramatically affect the pharmacological response. Thus, downregulation of SLC22A1, which encodes the organic cation transporter type 1 (OCT1), may affect the response of healthy hepatocytes and liver cancer cells to cationic drugs, such as metformin and sorafenib, respectively. Moreover, the overall picture may be modified to a considerable extent by the...

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PMID: 23984399
DOI: 10.1155/2013/692071
PMCID: PMC3747481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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