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The human organic cation transporter OCT1 and its role as a target for drug responses

28 Sept 2019

Abstract excerpt

The human organic cation uptake transporter OCT1, encoded by the SLC22A1 gene, is highly expressed in the liver and reported to possess a broad substrate specificity. OCT1 operates by facilitated diffusion and allows the entry of nutrients into cells. Recent findings revealed that OCT1 can mediate the uptake of drugs for treating various diseases such as cancers. The levels of OCT1 expression correlate with the...

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PMID: 31564168
DOI: 10.1080/03602532.2019.1670204

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