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Article

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation.

Genes and immunity - 1 Oct 2012

Munthe-Fog L, Hummelshoj T, Honoré C, Moller M E, Skjoedt M O, Palsgaard I, Borregaard N, Madsen H O, Garred P

Abstract excerpt

Ficolin-1 is a recognition molecule of the lectin complement pathway. The ficolin-1 gene FCN1 is polymorphic, but the functional and clinical consequences are unknown.The concentration of ficolin-1 in plasma and FCN1 polymorphisms in positions -1981 (rs2989727), -791 (rs28909068), -542 (rs10120023), -271 (rs28909976), -144 (rs10117466) and +7918 () were determined in 100 healthy individuals. FCN1...

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Share to Aged, 80 and over
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Source

Identifiers

PMID: 22673311
DOI: 10.1038/gene.2012.27

Genes

FCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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