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Article

Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors.

Molecular immunology - 1 Mar 2006

Herpers Bjorn Lars, Immink Marie-Monique, de Jong Ben A W, van Velzen-Blad Heleen, de Jongh Bartelt M, van Hannen Erik J

Abstract excerpt

Human L-ficolin (FCN) is a serum lectin characterized by a collagen-like and a fibrinogen-like domain that can activate the lectin pathway of complement. Structural and functional similarities to mannose-binding lectin (MBL) suggest a role for L-ficolin in innate immunity. Structural polymorphisms in the MBL2 gene lead to functional deficiency of MBL. Polymorphisms in the FCN2 gene have not been studied...

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Source

Identifiers

PMID: 16076493
DOI: 10.1016/j.molimm.2005.06.035

Genes

FCN2
MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors.PMID 16076493Read ↗

MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.Semantic proximity Read ↗

Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.Semantic proximity Read ↗

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2Semantic proximity Read ↗

Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns.Semantic proximity Read ↗

Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels.Semantic proximity Read ↗

Mannose-binding lectin and its genetic variants.Semantic proximity Read ↗

Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms.Semantic proximity Read ↗

Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children.Semantic proximity Read ↗

The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels.Semantic proximity Read ↗

Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms.Semantic proximity Read ↗

Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease.Semantic proximity Read ↗

Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.Semantic proximity Read ↗

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