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Article

MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.

Molecular immunology - 1 Sept 2009

Garred Peter, Honoré Christian, Ma Ying Jie, Munthe-Fog Lea, Hummelshøj Tina

Abstract excerpt

Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. Common variant alleles situated both in promoter and structural regions...

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Topics

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19501910
DOI: 10.1016/j.molimm.2009.05.005

Genes

MBL2
FCN1
FCN2
FCN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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