Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease.

Molecular immunology - 1 May 2007

Chapman Stephen J, Vannberg Fredrik O, Khor Chiea C, Segal Shelley, Moore Catrin E, Knox Kyle, Day Nicholas P, Davies Robert J O, Crook Derrick W, Hill Adrian V S

Abstract excerpt

L-ficolin is a pattern-recognition molecule which binds lipoteichoic acid and Gram-positive bacteria and activates the lectin pathway of complement. Five common functional polymorphisms have recently been identified in the FCN2 gene which encodes L-ficolin: three promoter polymorphisms (at positions -986, -602 and -4) which affect serum L-ficolin concentration, and two non-synonymous polymorphisms (Thr236Met and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Ficolins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Lectins

Share to Pneumococcal Infections

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17382393
DOI: 10.1016/j.molimm.2006.04.013

Genes

FCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease.PMID 17382393Read ↗

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2Semantic proximity Read ↗

Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.Semantic proximity Read ↗

Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease.Semantic proximity Read ↗

Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children.Semantic proximity Read ↗

Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns.Semantic proximity Read ↗

Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.Semantic proximity Read ↗

Polymorphisms of the FCN2 Gene 3'UTR Region and Their Clinical Associations in Preterm Newborns.Semantic proximity Read ↗

The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates.Semantic proximity Read ↗

Mannose-binding lectin and l-ficolin polymorphisms in patients with community-acquired pneumonia caused by intracellular pathogens.Semantic proximity Read ↗

Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors.Semantic proximity Read ↗

Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns.Semantic proximity Read ↗

The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.