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Article

Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children.

Clinical and experimental immunology - 1 Mar 2009

Ruskamp J M, Hoekstra M O, Postma D S, Kerkhof M, Bottema R W, Koppelman G H, Rovers M M, Wijga A H, de Jongste J C, Brunekreef B, Sanders E A M

Abstract excerpt

Ficolins are pattern-recognition molecules that appear to be relevant for innate immune defence against infections. The ficolin genes in Caucasians are polymorphic and genetic variations may have functional consequences, both in relation to function and concentration. Low levels of Ficolin-2 have...

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Source

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Identifiers

PMID: 19220833
DOI: 10.1111/j.1365-2249.2008.03844.x
PMCID: PMC2669519

Genes

FCN2
FCN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19220833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children.PMID 19220833Read ↗

Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.Semantic proximity Read ↗

Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns.Semantic proximity Read ↗

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Polymorphisms of the FCN2 Gene 3'UTR Region and Their Clinical Associations in Preterm Newborns.Semantic proximity Read ↗

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2Semantic proximity Read ↗

L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children.Semantic proximity Read ↗

The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia.Semantic proximity Read ↗

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The Clinical Value of Ficolin-3 Gene Polymorphism in Rheumatic Heart Disease. An Egyptian Adolescents StudySemantic proximity Read ↗

The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates.Semantic proximity Read ↗

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