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Article

The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates.

Human immunology - 1 Jul 2013

Kilpatrick David C, St Swierzko Anna, Matsushita Misao, Domzalska-Popadiuk Iwona, Borkowska-Klos Monika, Szczapa Jerzy, Cedzynski Maciej

Abstract excerpt

The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at -602, -4 and +6359 were associated with an increase, while mutations at -986, -557, -64 and +6424 were...

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Identifiers

PMID: 23619474
DOI: 10.1016/j.humimm.2013.04.011

Genes

FCN2

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