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Article

Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.

The Journal of experimental medicine - 19 Mar 2007

Min-Oo Gundula, Fortin Anny, Pitari Giuseppina, Tam Mifong, Stevenson Mary M, Gros Philippe

Abstract excerpt

Mouse strains AcB55 and AcB61 are resistant to malaria by virtue of a mutation in erythrocyte pyruvate kinase (Pklr(I90N)). Linkage analysis in [AcB55 x A/J] F2 mice detected a second locus (Char9; logarithm of odds = 4.74) that regulates the blood-stage replication of Plasmodium chabaudi AS independently of Pklr. We characterized the 77 genes of the Char9 locus for tissue-specific expression, strain-specific...

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Identifiers

PMID: 17312006
DOI: 10.1084/jem.20061252
PMCID: PMC2137903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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