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Article

Pyruvate kinase deficiency in mice protects against malaria.

Nature genetics - 1 Dec 2003

Min-Oo Gundula, Fortin Anny, Tam Mi-Fong, Nantel André, Stevenson Mary M, Gros Philippe

Abstract excerpt

The global health impact of malaria is enormous, with an estimated 300-500 million clinical cases and 1 million annual deaths. In humans, initial susceptibility to infection with Plasmodium species, disease severity and ultimate outcome of malaria (self-healing or lethal) are under complex genetic control. Alleles associated with sickle cell anemia, beta-thalassemia and deficiency in glucose-6-phosphate...

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Identifiers

PMID: 14595440
DOI: 10.1038/ng1260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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