Article
Genetic control of host-pathogen interactions in mice.
Novartis Foundation symposium - 1 Jan 2007
Min-Oo Gundula, Stevenson Mary M, Fortin Anny, Gros Philippe
Abstract excerpt
The onset, progression and outcome of infections are determined by performance of host defence mechanisms and expression of pathogen virulence determinants. Genetic analysis in mouse can identify host genes that play critical roles at the interface of host-pathogen interactions. Genetic effects detected as variations in susceptibility in inbred, recombinant and mutant strains of mice can be mapped as simple...
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