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Article

Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.

Genes and immunity - 1 Mar 2010

Min-Oo G, Willemetz A, Tam M, Canonne-Hergaux F, Stevenson M M, Gros P

Abstract excerpt

Resistance to blood-stage malaria in AcB55 and AcB61 is caused by a loss of function mutation in pyruvate kinase (Pklr(I90N)). Likewise, pyruvate kinase (PK) deficiency in humans is protective against Plasmodium replication in vitro. We identified a third AcB strain, AcB62 that also carries the Pklr(I90N) mutation. However, AcB62 mice were susceptible to P.chabaudi infection and showed high levels of parasite...

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Share to Anemia, Hemolytic, Congenital
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19865104
DOI: 10.1038/gene.2009.78

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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