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Article

The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.

PloS one - 1 Jan 2017

Laroque Aurélie, Min-Oo Gundula, Tam Mifong, Ponka Prem, Stevenson Mary M, Gros Philippe

Abstract excerpt

Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective PklrI90N genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic modifier of the PklrI90N protective effect. Linkage analysis in a F2 cross between AcB62 (PklrI90N) and another PK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28542307
DOI: 10.1371/journal.pone.0177818
PMCID: PMC5436716

Genes

PKLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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