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Article

Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model.

Genes and immunity - 1 May 2004

Min-Oo G, Fortin A, Tam M-F, Gros P, Stevenson M M

Abstract excerpt

The recombinant congenic mouse strains AcB55 and AcB61 are extremely resistant to malaria (Plasmodium chabaudi AS) despite the presence of susceptibility alleles at the known Char1/Char2 resistance loci. Resistance in AcB55 and AcB61 is controlled by a locus on chromosome 3 (Char4) shown to be allelic with or tightly linked to a loss-of-function mutation in pyruvate kinase (Pklr). AcB55 and AcB61 show important...

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PMID: 15029238
DOI: 10.1038/sj.gene.6364069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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