Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2021

Hamano Fumie, Matoba Kazuaki, Hashidate-Yoshida Tomomi, Suzuki Tomoyuki, Miura Kiyotake, Hishikawa Daisuke, Harayama Takeshi, Yuki Koichi, Kita Yoshihiro, Noda Nobuo N, Shimizu Takao, Shindou Hideo

Abstract excerpt

Platelet-activating factor (PAF) is a potent proinflammatory phospholipid mediator that elicits various cellular functions and promotes several pathological events, including anaphylaxis and neuropathic pain. PAF is biosynthesized by two types of lyso-PAF acetyltransferases: lysophosphatidylcholine acyltransferase 1 (LPCAT1) and LPCAT2, which are constitutive and inducible forms of lyso-PAF acetyltransferase,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyl Coenzyme A
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalytic Domain

Share to Models, Molecular

Share to Molecular Dynamics Simulation

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Sequence Homology

Source

Identifiers

PMID: 33956375
DOI: 10.1096/fj.202002591R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.PMID 33956375Read ↗

Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1.Semantic proximity Read ↗

Structural basis of substrate discrimination and integrin binding by autotaxin.Semantic proximity Read ↗

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7Semantic proximity Read ↗

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations.Semantic proximity Read ↗

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.Semantic proximity Read ↗

LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in miceSemantic proximity Read ↗

The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancerSemantic proximity Read ↗

The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in Cryptococcus neoformansSemantic proximity Read ↗

Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinaseSemantic proximity Read ↗

Structure and function of carnitine acyltransferases.Semantic proximity Read ↗

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.Semantic proximity Read ↗

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.