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Article

Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme.

Journal of lipid research - 1 Nov 2013

Hiraoka Miki, Okamoto Ken, Ohguro Hiroshi, Abe Akira

Abstract excerpt

To understand the role of N-glycosylation of lysosomal phospholipase A2 (LPLA2), four potential N-glycosylation sites in human LPLA2 (hLPLA2) were individually modified replacing asparagine (Asn) with alanine by site-direct mutagenesis. COS-7 cells transiently transfected with wild-type (WT) hLPLA2 gene produced catalytically active LPLA2. A single mutation at 273-, 289-, or 398-Asn partially reduced production...

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Identifiers

PMID: 23958596
DOI: 10.1194/jlr.M041640
PMCID: PMC3793614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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