Article
In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
Pharmacological research - 1 Apr 2007
Imbimbo Bruno P, Del Giudice Elda, Cenacchi Valentina, Volta Roberta, Villetti Gino, Facchinetti Fabrizio, Riccardi Benedetta, Puccini Paola, Moretto Nadia, Grassi Francesca, Ottonello Simone, Leon Alberta
Abstract excerpt
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) may delay or prevent the onset of Alzheimer's disease (AD). A subset of NSAIDs, including flurbiprofen, has been shown to selectively inhibit the production of beta-amyloid(1-42) (Abeta42), independently from their cyclooxygenase (COX) inhibiting activity. We evaluated the in vitro and in vivo profiles of CHF5022 and CHF5074, two flurbiprofen...
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