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Article

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.

Journal of neurochemistry - 1 Jan 2013

Choi Sang-Ho, Aid Saba, Caracciolo Luca, Minami S Sakura, Niikura Takako, Matsuoka Yasuji, Turner R Scott, Mattson Mark P, Bosetti Francesca

Abstract excerpt

Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroinflammation. However, follow-up clinical trials, mostly using selective cyclooxygenase (COX)-2 inhibitors, failed to show any beneficial effect in AD patients with mild...

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Identifiers

PMID: 23083210
DOI: 10.1111/jnc.12059
PMCID: PMC3780364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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