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Article

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.

Annals of neurology - 1 Nov 2012

Shi Ju, Wang Qian, Johansson Jenny U, Liang Xibin, Woodling Nathaniel S, Priyam Prachi, Loui Taylor M, Merchant Milton, Breyer Richard M, Montine Thomas J, Andreasson Katrin

Abstract excerpt

OBJECTIVE: There is significant evidence for a central role of inflammation in the development of Alzheimer disease (AD). Epidemiological studies indicate that chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD in healthy aging populations. As NSAIDs inhibit the enzymatic activity of the inflammatory cyclooxygenases COX-1 and COX-2, these findings suggest that...

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PMID: 22915243
DOI: 10.1002/ana.23677
PMCID: PMC3509238

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